Department of Pharmacology and Clinical Neuroscience
Pharmacology Unit

Test your knowledge of Pharmacology


Umeå universitet
Pharmacology Brain Teasers

The importance of pharmacokinetics (what the body does to the drug). All the questions share a common denominator - that whatever the molecular mechanism of action, pharmakokinetic differences between drugs can cause all sorts of interesting effects.

• Terfenadine and grapefruit juice
• Can antibiotics get you pregnant ?
• Mr Smith, Mr Jones, and digoxin
• St John's wort (Johannesört) and drug metabolism
• Auntie Flo's iron pills

Drug-receptor interactions and general pharmacodynamic principles. Agonist, partial inverse agonist, quantal dose-response curves... all that terminology!

• Quantal and graded dose-response curves
• Affinity and efficacy
• Inverse agonists and the two-state model
• Efficacy and potencies at receptors - an example from the recent litterature
• Different receptor families
• Tachyphalyxis and tolerance

Pharmacokinetics for purists. In this section, basic pharmacokinetic principles are discussed. It may not be that sexy, but it's important!

• Patient age and drug half life
• Zero order pharmacokinetics
• Drug accumulation in breast milk
• "Slow" and "fast" CYP2D6 oxidisers
• The unavoidable calculation question

Drugs affecting the central nervous system. In this section, mechanisms of action of drugs used as antidepressants, antipsychotics and for the treatment of Parkinson's diserase are discussed.

• L-DOPA and the "on-off" phenomenon
• Depression in the elderly
• Typical and Atypical Neuroleptics
• Mechanism of action of benzodiazepines
• Why measure plasma lithium levels?
• The incidence of Alzheimer's disease - pharmacological influences
• Phenytoin and the treatment of epilepsy

The autonomic nervous system. Who says you can't control the autonomic nerve system with free will - you can choose to take a drug like clonidine that affects sympathetic outflow!

• Myasthenia gravis and cholinesterase inhibition
• The strange mechanism of action of suxamethonium
• Imipramine, reserpine, and the noradrenergic varicosity
 

Treatment of allergies and asthma. Asthma affects about 5% of the population (8% of young people in northern Sweden). Test your knowledge about available treatments.

• Grumpy Uncle Henry and his glucocorticoids
• Propranolol and asthma
• Beta2 adrenoceptor agonists with different indications
• Antihistamines and tiredness
• A new treatment for allergic rhinitis?

Cardiovascular pharmacology. The heart is a tough old tissue, and believe me, cardiovasular pharmacology is tough!

• Atrial arrythmias and verapamil
• Treatment of heart failure
• Organic nitrates and sidenafil (Viagra™)
• Furosemide and non-steroidal anti-inflammatory drugs
• Mechanism of action of thiazide diuretics
• How do digitalis glycosides work?

Analgesics and anaesthetics. No pain no gain, but unneccessary pain should be treated when possible

• Codeine and antidepressants - an unwise combination?
• Morphine tolerance
• Non-opioid effects of tramadol
• NSAID's and gastro-intestinal damage
• NSAID's and infertility
• Isoflurane, desflurane and sevoflurane

Drugs of abuse and treatment strategies. "Drugs" is a term that applies not only to compounds that havetherapeutic usefulness, but also to compounds that are taken recreationally, often with disasterous consequences for the individual and for society.

• Amphetamine part 1
• Amphetamine part 2
• The use of disulfiram

Bits and bobs. Pharmacology is so much more than just the categories listed above. Eventually some of the questions below will get their own categories, but for now they are lumped together.

• Treatment of nausea and emesis
• Why combine cytostatic agents?
• Anticoagulants work at different speeds
• Alternatives to serendipity in drug discovery
• Pharmacological treatment of hyperthyreosis

 

 

What this quiz does: Test your knowledge about drugs and how they work.

What this quiz doesn't: Give treatment recommendations or make diagnoses.

 

 

Umeå university

Faculty of Medicine

Department of Pharmacology and Clinical Neuroscience

 

Umeå universitet

Medicinska fakulteten

Institutionen för farmakologi och klinisk neurovetenskap

Avdelningen för farmakologi

 

 

 

 

 


Department of Pharmacology and Clinical Neuroscience
Umeå university
The information on this page was checked on 1 April 2004
Responsible for this page: Christopher Fowler